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Synthesis of tinidazole by condensation–oxidation sequence using MoO3/SiO2 bifunctional catalyst

Paper ID Volume ID Publish Year Pages File Format Full-Text
52331 46869 2007 6 PDF Available
Title
Synthesis of tinidazole by condensation–oxidation sequence using MoO3/SiO2 bifunctional catalyst
Abstract

Antimicrobial drug, tinidazole has been synthesized by condensation of 2-methyl,5-nitro-imidazole and 2-ethyl-thio-ethanol over MoO3/SiO2 catalyst to obtain 1-(2-ethyl-thio-ethanol)-2-methyl-5-nitro-imidazole which is further oxidized using hydrogen peroxide using the same MoO3/SiO2 catalyst to obtain tinidazole. MoO3/SiO2 catalyst (20%), synthesized by sol–gel process showed the highest acid strength and was successfully demonstrated to catalyze both condensation and oxidation in the synthesis of tinidazole. Due to the bifunctional activity of the catalyst, the use of acetic acid for condensation step and tungstic acid or ammonium molybdate for oxidation step in the conventional synthesis of tinidazole could be eliminated, thus making it an environmentally benign process. The catalysts could be recycled five times without any appreciable loss in the conversion and selectivity showing the potential for the use of MoO3/SiO2 as bifunctional catalyst for the production of this industrially important compound.

Keywords
Tinidazole; Antimicrobial drug; Solid acid catalyst; MoO3/SiO2; Condensation; Oxidation
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Synthesis of tinidazole by condensation–oxidation sequence using MoO3/SiO2 bifunctional catalyst
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 8, Issue 10, October 2007, Pages 1550–1555
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us