fulltext.study @t Gmail

Catalytic hydrogenation for the industrial synthesis of the Wong’s anthracyclines intermediate

Paper ID Volume ID Publish Year Pages File Format Full-Text
52411 46873 2006 5 PDF Available
Title
Catalytic hydrogenation for the industrial synthesis of the Wong’s anthracyclines intermediate
Abstract

A new catalytic synthesis of the Wong’s antracyclines intermediate, (R)-2-acetyl-2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydronapthlene, starting from the corresponding 1,2-diol has been discovered through its selective hydrogenolysis in the presence of palladium heterogeneous catalysts. High yield and no racemization were found under mild reaction conditions: the molar selectivity towards the target product was always higher than 99.5%. The catalytic performances resulted strongly dependent on the nature of the palladium catalyst, unreduced Pd/C showing the best performances. This straightforward catalytic route significantly improves the up to now adopted industrial process.

Keywords
Antibiotics; Antitumor agents; Palladium; Hydrogenation; Heterogeneous catalysis
First Page Preview
Catalytic hydrogenation for the industrial synthesis of the Wong’s anthracyclines intermediate
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 7, Issue 11, November 2006, Pages 896–900
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us