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Production of trehalase inhibitor validoxylamine A using acid-catalyzed hydrolysis of validamycin A

Paper ID Volume ID Publish Year Pages File Format Full-Text
52731 46883 2006 5 PDF Available
Title
Production of trehalase inhibitor validoxylamine A using acid-catalyzed hydrolysis of validamycin A
Abstract

As a competitive trehalase inhibitor and lead compound with broad uses, validoxylamine A has been increasingly studied for its many possible applications. The process of acid-catalyzed hydrolysis of validamycin A was investigated for production of validoxylamine A. The effects of various acids and substrate concentrations were explored, and the mechanism of acid-catalyzed hydrolysis of validamycin A was proposed. Results demonstrated that the optimal condition of acid hydrolysis of validamycin A included 1 M H2SO4 and a 30% (w/v) initial validamycin A concentration in a 1 h reaction time.

Keywords
Acid hydrolysis; Trehalase inhibitor; Validamycin A; Validoxylamine A
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Production of trehalase inhibitor validoxylamine A using acid-catalyzed hydrolysis of validamycin A
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 7, Issue 3, March 2006, Pages 157–161
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us