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Strain-induced crack formations in PDMS/DXA drug collars

Paper ID Volume ID Publish Year Pages File Format Full-Text
529 46 2013 8 PDF Available
Title
Strain-induced crack formations in PDMS/DXA drug collars
Abstract

Drug-eluting systems are currently used in cardiac leads in order to reduce inflammation and fibrosis at the lead–tissue interface. Drug release from these drug delivery systems can be modulated by the manufacturing processes used to create the drug systems and assemble them onto the cardiac lead. In this study, scanning electron microscopy, atomic force microscopy and Raman microscopy are employed to explore the material characteristics of a polydimethylsiloxane–dexamethasone acetate drug collar used on cardiac leads when varying the strain during collar assembly on the lead. A novel test fixture was created in order to investigate these drug collars under simulated stresses. Measurements of the collar while fitted to a rod revealed microcracks that are hypothesized to affect the drug release performance, resulting in increased drug elution. It was found that the strain that occurs during assembly of the collar onto the lead is a key factor in the formation of these microcracks. Results also suggest that cracks tend to form in areas of high drug particle density, and propagate between drug particles.

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Keywords
AFM (atomic force microscopy); Controlled drug release; SEM (scanning electron microscopy); Polydimethylsiloxane; Raman microscopy
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Strain-induced crack formations in PDMS/DXA drug collars
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 7, July 2013, Pages 7335–7342
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us