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ZrO2-pillared clay: An efficient catalyst for solventless synthesis of biologically active multifunctional dihydropyrimidinones

Paper ID Volume ID Publish Year Pages File Format Full-Text
52913 46891 2006 8 PDF Available
Title
ZrO2-pillared clay: An efficient catalyst for solventless synthesis of biologically active multifunctional dihydropyrimidinones
Abstract

A novel protocol using ZrO2-pillared clay (Zr-PILC), prepared by us as a mild recyclable solid acid catalyst for multicomponent one-pot synthesis of dihydropyrimidinones under solvent free conditions both by thermal and microwave heating using the Bronsted and Lewis acidity (proposed mechanism) of Zr-PILC is reported. The efficacy of the procedure is exemplified by the synthesis of biologically active racemic mixture of monastrol and nitractin (a potent lead anti-cancer drug and antibacterial, antiviral drug, respectively).

Keywords
ZrO2-pillared clay; Solventless dihydropyrimidinones; MW; monastrol; nitractin
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ZrO2-pillared clay: An efficient catalyst for solventless synthesis of biologically active multifunctional dihydropyrimidinones
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 7, Issue 8, August 2006, Pages 571–578
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us