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LiClO4 · 3H2O promoted highly regioselective ring-opening of epoxides with thiols under neutral conditions

Paper ID Volume ID Publish Year Pages File Format Full-Text
53049 46898 2006 4 PDF Available
Title
LiClO4 · 3H2O promoted highly regioselective ring-opening of epoxides with thiols under neutral conditions
Abstract

A simple, rapid, atom economy and highly efficient procedure has been developed for thiolysis of epoxides by aromatic and aliphatic thiols under solvent-free conditions. A high regioselectivity in favor of nucleophilic attack at the benzylic carbon atom of aromatic epoxides, such as styrene oxide, is observed. However, aliphatic unsymmetrical alkenyl oxides undergo selective nucleophilic attack at the sterically less hindered carbon atom. A variety of β-hydroxy sulfides were obtained in short reaction time and excellent yields with nearly complete regioselectivity.

Keywords
Protection; LiClO4 · 3H2O; Solvent-free conditions; Atom economy; Epoxides; Thiol
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LiClO4 · 3H2O promoted highly regioselective ring-opening of epoxides with thiols under neutral conditions
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 7, Issue 4, April 2006, Pages 224–227
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us