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Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs

Paper ID Volume ID Publish Year Pages File Format Full-Text
5336 367 2016 9 PDF Available
Title
Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs
Abstract

Malignant glioma is one of the most common intracranial tumor with a dismal prognosis. The radiosensitizing effect of silver nanoparticles (AgNPs) on glioma both in vitro and in vivo were demonstrated in the previous studies of our group. However, the underlying mechanism is still unclear. In this present study, the use of antioxidants is employed for the regulating of reactive oxygen species (ROS) in U251 cells treated with various agents, and the results shows that ROS played an essential role in the autophagy inducing and radiosensitization effect of AgNPs. Moreover, the inhibition of protective autophagy with 3-MA is another way to increase ROS, resulting in the increasing of cell death and apoptosis. Taken together, understanding the relationship between the elevated ROS and autophagy and the effect of ROS should be useful to the clinical applications of AgNPs. These findings could potentially be exploited for new therapeutic strategies in glioma radiotherapy.

Keywords
Silver nanoparticles; Autophagy; Glioma; Radiotherapy; Radiation sensitization; Reactive oxygen species (ROS)
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Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 101, September 2016, Pages 1–9
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us