fulltext.study @t Gmail

Osteogenic signaling on silk-based matrices

Paper ID Volume ID Publish Year Pages File Format Full-Text
5363 370 2016 21 PDF Available
Title
Osteogenic signaling on silk-based matrices
Abstract

Bone tissue engineering has mainly focused on generating 3D grafts to repair bone defects. However, the underlying signaling mechanisms responsible for development of such 3D bone equivalents have largely been ignored. Here we describe the crucial aspects of embryonic osteogenesis and bone development including cell sources and general signaling cascades that guide mesenchymal progenitors towards osteogenic lineage. Drawing from the knowledge of developmental biology, we then review how silk biomaterial can regulate osteogenic signaling by focusing on the expression of cell surface markers, functional genomic information (mRNA) of stem cells cultured on silk matrices. In an attempt to recapitulate exact in vivo microenvironment of osteogenesis, role of scaffold architecture and material chemistry in regulating cellular differentiation is elaborated. The generated knowledge will not only improve our understanding of cell-material interactions but reveal newer strategies beyond a conventional tissue engineering paradigm and open new prospects for developing silk-based therapies against clinically relevant bone disorders.

Graphical abstractKnowledge on the mechanism of bone development and the corresponding signaling cascades is vital for the development of functional 3D bone graft models. This review focuses on the osteogenic potential of silk-based matrices and the underlying signaling mechanisms that regulate osteogenesis as a function of the physical (scaffold topography and pore architecture), chemical (decorated chemical groups) and biological (cell sources and immobilized/soluble growth factors) factors.Figure optionsDownload full-size imageDownload high-quality image (346 K)Download as PowerPoint slide

Keywords
Silk fibroin; Mulberry and non-mulberry; Osteogenic signaling; Bone regeneration
First Page Preview
Osteogenic signaling on silk-based matrices
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 97, August 2016, Pages 133–153
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us