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Photocatalytic degradation of three amantadine antiviral drugs as well as their eco-toxicity evolution

Paper ID Volume ID Publish Year Pages File Format Full-Text
53638 46977 2015 8 PDF Available
Title
Photocatalytic degradation of three amantadine antiviral drugs as well as their eco-toxicity evolution
Abstract

•Bimolecular reaction rate constants of OH with antiviral drugs were determined.•Photocatalytic degradation kinetics of three antiviral drugs were controlled by pH.•The dominated ROSs was confirmed as OH using different scavengers’ addition.•The ecotoxicities of three antiviral drugs were evaluated before and after degradation.

sAdvanced oxidation processes (AOPs) relying on in situ generated highly reactive OH are successfully applied to water purification. The absolute reaction rate constants for OH with three antiviral drugs were first reported through pulsed radiolysis experiments. Results found that OH reacted quickly with these substrates, with bimolecular reaction rate constants of 6.31 × 109, 5.13 × 109, and 7.05 × 109 M−1s−1 for 1-amantadine, 2-amantadine, and rimantadine, respectively. The photocatalytic degradation kinetics of substrates were followed pseudo-first-order kinetics according to Langmuir–Hinshelwood model in TiO2 suspensions, and the apparent rate constants were obtained as 0.076, 0.084, and 0.102 min−1 for three antiviral drugs, respectively. Scavenger experiments revealed that OH was the major reactive species involved in antiviral drugs degradation. To probe the photocatalytic degradation mechanism, the fate of nitrogen elements and the change of total organic carbon were also examined, and the data showed that all three drugs could be completely mineralized into CO2, H2O, and inorganic ions (NO3− and NH4+) without generating any detectable products with enough degradation time. To further insight into the potential adverse effect of three antiviral drugs and their degradation products, the acute aquatic toxicity of degradation solutions were evaluated at three different trophic levels, and the toxicities first increased slightly and then decreased rapidly as the total organic carbon decreased.

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Keywords
Photocatalytic degradation; Antiviral drug; Kinetics; Reactive oxygen species; Ecotoxicity assessment
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Photocatalytic degradation of three amantadine antiviral drugs as well as their eco-toxicity evolution
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Today - Volume 258, Part 2, 1 December 2015, Pages 602–609
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us