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Human relaxin gene expression delivered by bioreducible dendrimer polymer for post-infarct cardiac remodeling in rats

Paper ID Volume ID Publish Year Pages File Format Full-Text
5375 370 2016 12 PDF Available
Title
Human relaxin gene expression delivered by bioreducible dendrimer polymer for post-infarct cardiac remodeling in rats
Abstract

In consensus, myocardial infarction (MI) is defined as irreversible cell death secondary to prolonged ischemia in heart. The aim of our study was to evaluate the therapeutic potential of anti-fibrotic human Relaxin-expressing plasmid DNA with hypoxia response element (HRE) 12 copies (HR1) delivered by a dendrimer type PAM-ABP polymer G0 (HR1/G0) after MI on functional, hemodynamic, geometric, and cardiac extracellular matrix (ECM) remodeling in rats. HR1/G0 demonstrated significantly improved LV systolic function, hemodynamic parameters, and geometry on 1 wk and 4 wks after MI in rats, compared with I/R group. The resolution of regional wall motional abnormalities and the increased blood flow of infarct-related coronary artery supported functional improvements of HR1/G0. Furthermore, HR1/G0 polyplex showed favorable post-infarct cardiac ECM remodeling reflected on the favorable cardiac ECM compositions. Overall, this is the first study, which presented an advanced platform for the gene therapy that reverses adverse cardiac remodeling after MI with a HR1 gene delivered by a bioreducible dendrimer polymer in the cardiac ECM.

Keywords
Relaxin gene therapy; Myocardial infarction; Bioreducible polymer; Dendrimer; Cardiac extracellular matrix (ECM); Post-infarct remodeling; Infarct-related coronary artery
First Page Preview
Human relaxin gene expression delivered by bioreducible dendrimer polymer for post-infarct cardiac remodeling in rats
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 97, August 2016, Pages 164–175
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering