fulltext.study @t Gmail

Synthesis of the antimalarial API artemether in a flow reactor

Paper ID Volume ID Publish Year Pages File Format Full-Text
54003 46992 2015 7 PDF Available
Title
Synthesis of the antimalarial API artemether in a flow reactor
Abstract

•Catalytic flow synthesis of artemether was shown for the first time.•A stable etherification catalyst was found.•LCA study highlighted critical stages of the process.•Tandem reduction-etherification in flow is feasible.

The earlier developed flow protocol for stoichiometric reduction of an important biologically derived pharmaceutical precursor, artemisinin, to dihydroartemisinin was extended to a sequential reaction to produce one of the final APIs, artemether. A highly active heterogeneous catalyst was found for the etherification reaction. The use of QuadraSil catalyst allows to eliminate one step of reaction workup. A comparative Life Cycle Assessment of both reactions has shown advantages of the flow process over the optimized literature batch protocols. Results of LCA highlight the significance of solvents in pharmaceuticals manufacture and the advantage of flow technology, enabling small solvent inventories to be used.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (89 K)Download as PowerPoint slide

Keywords
Flow chemistry; Artemisinin; Malaria; Life cycle assessment; Acid catalysis
First Page Preview
Synthesis of the antimalarial API artemether in a flow reactor
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Today - Volume 239, 1 January 2015, Pages 90–96
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us