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A critical review of cell culture strategies for modelling intracortical brain implant material reactions

Paper ID Volume ID Publish Year Pages File Format Full-Text
5439 385 2016 21 PDF Available
Title
A critical review of cell culture strategies for modelling intracortical brain implant material reactions
Abstract

The capacity to predict in vivo responses to medical devices in humans currently relies greatly on implantation in animal models. Researchers have been striving to develop in vitro techniques that can overcome the limitations associated with in vivo approaches. This review focuses on a critical analysis of the major in vitro strategies being utilized in laboratories around the world to improve understanding of the biological performance of intracortical, brain-implanted microdevices. Of particular interest to the current review are in vitro models for studying cell responses to penetrating intracortical devices and their materials, such as electrode arrays used for brain computer interface (BCI) and deep brain stimulation electrode probes implanted through the cortex. A background on the neural interface challenge is presented, followed by discussion of relevant in vitro culture strategies and their advantages and disadvantages. Future development of 2D culture models that exhibit developmental changes capable of mimicking normal, postnatal development will form the basis for more complex accurate predictive models in the future. Although not within the scope of this review, innovations in 3D scaffold technologies and microfluidic constructs will further improve the utility of in vitro approaches.

Keywords
Cell culture; Intracortical implants; Central nervous system wound healing; Glial scar; In vitro model
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A critical review of cell culture strategies for modelling intracortical brain implant material reactions
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 91, June 2016, Pages 23–43
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us