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3D scaffolds in breast cancer research

Paper ID Volume ID Publish Year Pages File Format Full-Text
5460 388 2016 22 PDF Available
3D scaffolds in breast cancer research

Breast tumors grow in a tissue microenvironment containing extracellular matrix (ECM), adipocytes, stromal cells, fluids, and blood vessels. This natural yet complex physiopathological territory is dynamically remodeled in favor of tumor growth and metastasis. The environment-mimicking 3D cultures have shown compelling advantages in the studies of tumor cell biology, and are of intensive research for the development of alternative systems to improve therapeutic efficacies against tumors. This review focuses on the most recent advances in scaffolding techniques, the cell-ECM and cell-cell interactions in scaffold cultures, the distinct physical properties and signaling regulation of cancer cell growth within the scaffolds, the sensitivities of the cancer cells to drugs in 3D culture, and the use of scaffolds for drug delivery into tumors.

Breast tumor; Extracellular matrix; 3D scaffold; Cell-ECM interaction; Signaling; Drug delivery
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3D scaffolds in breast cancer research
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 81, March 2016, Pages 135–156
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Physical Sciences and Engineering Chemical Engineering Bioengineering