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Mononuclear gold catalysts for the asymmetric intramolecular hydroamination of alkenes

Paper ID Volume ID Publish Year Pages File Format Full-Text
54671 47020 2014 12 PDF Available
Title
Mononuclear gold catalysts for the asymmetric intramolecular hydroamination of alkenes
Abstract

•The intramolecular gold catalysed asymmetric hydroamination of alkenes was studied.•A series of mononuclear gold(I) and (III) complexes was combined with silver salts.•The best catalysts arose from BINOL based phosphoramidite ligands.•The resulting gold(I) complexes were efficient catalysts at mild temperatures.•Good conversions and average enantioselectivities were obtained.

The intramolecular gold catalysed asymmetric hydroamination of alkenes was studied screening a series of mononuclear gold(I) and (III) complexes in combination with silver salts. Among the various chiral mono-phosphine and diaminocarbene ligands tried, the best catalysts arose from mononuclear gold(I) complexes synthesized from BINOL based phosphoramidite ligands. The latest were improved by addition of bulky substituents at specific positions of the BINOL scaffold. The resulting gold(I) complexes were combined with selected silver salts to afford efficient catalysts for intramolecular hydroamination of alkenes at mild temperatures, with good conversions and average enantioselectivities.

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Keywords
Hydroamination; Alkenes; Amines; Gold; N-heterocycles
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Mononuclear gold catalysts for the asymmetric intramolecular hydroamination of alkenes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Today - Volume 235, 15 October 2014, Pages 2–13
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
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Price was $35.95
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