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The in vivo performance of CaP/PLGA composites with varied PLGA microsphere sizes and inorganic compositions

Paper ID Volume ID Publish Year Pages File Format Full-Text
547 46 2013 9 PDF Available
Title
The in vivo performance of CaP/PLGA composites with varied PLGA microsphere sizes and inorganic compositions
Abstract

Enrichment of calcium phosphate (CaP) bone substitutes with poly(lactic-co-glycolic acid) (PLGA) microspheres to create porosity overcomes the problem of poor CaP degradation. The degradation of CaP–PLGA composites can be customized by changing the physical and chemical properties of PLGA and/or CaP. However, the effect of the size of dense (solid rather than hollow) PLGA microspheres in CaP has not previously been described. The present study aimed at determining the effect of different dense (i.e. solid) PLGA microsphere sizes (small (S) ∼20 μm vs. large (L) ∼130 μm) and of CaP composition (CaP with either anhydrous dicalcium phosphate (DCP) or calcium sulphate dihydrate (CSD)) on CaP scaffold biodegradability and subsequent bone in-growth. To this end mandibular defects in minipigs were filled with pre-set CaP–PLGA implants, with autologous bone being used as a control. After 4 weeks the autologous bone group outperformed all CaP–PLGA groups in terms of the amount of bone present at the defect site. On the other hand, at 12 weeks substantial bone formation was observed for all CaP–PLGA groups (ranging from 47 ± 25% to 62 ± 15%), showing equal amounts of bone compared with the autologous bone group (82 ± 9%), except for CaP with DCP and large PLGA microspheres (47 ± 25%). It was concluded that in the current study design the difference in PLGA microsphere size and CaP composition led to similar results with respect to scaffold degradation and subsequent bone in-growth. Further, after 12 weeks all CaP–PLGA composites proved to be effective for bone substitution.

Keywords
Bone substitution; PLGA; Pore size; Calcium phosphate; Pre-clinical
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The in vivo performance of CaP/PLGA composites with varied PLGA microsphere sizes and inorganic compositions
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 7, July 2013, Pages 7518–7526
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us