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Bifunctional mesoporous MCF materials as catalysts in the Friedländer condensation

Paper ID Volume ID Publish Year Pages File Format Full-Text
54752 47025 2013 6 PDF Available
Title
Bifunctional mesoporous MCF materials as catalysts in the Friedländer condensation
Abstract

•Bifunctional MCF materials are efficient catalysts for the Friedländer reaction.•The presence of metallic centers and amine groups over MCF supports enhances the catalytic activity.•Cooperative catalysis mechanism could justify the catalytic behavior of AP/T-MCF.

We report herein the Friedländer reaction of 2-aminoaryl aldehydes 1 and ethyl acetatoacetate (2) affording the corresponding quinolines 3. The condensation selectively leads to quinolines 3 with good to excellent yields under mild reaction conditions.The first step of the condensation is the Knoevenagel reaction between reagents as experimentally confirmed.In addition, in order to justify our results we carried out a computational study based on DFT calculations analyzing this first step of the condensation. In this sense, we propose a cooperative catalysis mechanism involving the amine functions and metallic centers both of them acting as activating agents of the reagents and, therefore, favoring the process.

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Keywords
Mesoporous materials; Niobiosilicates; Quinolines; Friedländer reaction; Computational studies
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Today - Volumes 218–219, December 2013, Pages 70–75
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
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Price was $35.95
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