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Nano-organocatalysts synthesis: Boc vs Fmoc protection

Paper ID Volume ID Publish Year Pages File Format Full-Text
54848 47028 2013 7 PDF Available
Title
Nano-organocatalysts synthesis: Boc vs Fmoc protection
Abstract

We report the elaboration of new l-Proline functionalized superparamagnetic iron oxide nanoparticles that can act as a new enantioselective organocatalyst. Boc-l-Proline and Fmoc-l-Proline are grafted using two different methodologies on a nanoplateform constituted of 10 nm maghemite (γ-Fe2O3) nanoparticle stabilized by bidendate coating agent Alendronate. We show that coupling is far more efficient using microwave assisted methodology and that only Fmoc deprotection is compatible with our nanoplatform. Moreover the fluorenyl group is used for indirect quantification of grafted Proline onto nanoparticles.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (85 K)Download as PowerPoint slideHighlights► Elaboration of l-Proline functionalized iron oxide nanoparticles. ► Comparison of Boc and Fmoc strategies for the obtaining of the nano-organocatalyst. ► Complete characterization of the nano-organocatalyst. ► Uses of fluorenyl deprotection for the indirect quantification of grafted Proline. ► Enhancement of Proline grafting by using microwave assisted conditions.

Keywords
Proline; Nano-organocatalyst; Iron oxide nanoparticles; Microwave; Boc, Fmoc deprotection
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Today - Volume 208, 1 June 2013, Pages 90–96
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us