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BaHoF5 nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke

Paper ID Volume ID Publish Year Pages File Format Full-Text
5490 392 2015 9 PDF Available
Title
BaHoF5 nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke
Abstract

CT angiography (CTA) and CT perfusion (CTP) imaging can play important roles in the workup of acute ischemic stroke. However, these techniques are hindered by the large amounts of contrast agents (CAs) required, high doses of X-ray radiation exposure, and nephrotoxicity of the clinical used iodinated CAs. To address these problems, we synthesized and validated a novel class of CT CAs, PEGylated BaHoF5 nanoparticles (NPs), for CTA and CTP imaging, which can greatly enhance the diagnostic sensitivity and accuracy of ischemic stroke. These agents have unique advantages over conventional iodinated CT agents, including much lower dosage required, major metabolism through liver and better imaging efficiency at different voltages. Once translated, these PEGylated BaHoF5 NPs can replace iodine-based CAs for diagnostic contrast-enhanced imaging of patients with kidney/heart diseases and improve the overall diagnostic index with negligible side effects.

Keywords
BaHoF5 nanoparticles; Multi-modal CT imaging; CT perfusion imaging; CT angiography imaging; Ischemic stroke
First Page Preview
BaHoF5 nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 71, December 2015, Pages 110–118
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering