fulltext.study @t Gmail

Doxorubicin encapsulated in stealth liposomes conferred with light-triggered drug release

Paper ID Volume ID Publish Year Pages File Format Full-Text
5520 394 2016 10 PDF Available
Title
Doxorubicin encapsulated in stealth liposomes conferred with light-triggered drug release
Abstract

Stealth liposomes can be used to extend the blood circulation time of encapsulated therapeutics. Inclusion of 2 molar % porphyrin-phospholipid (PoP) imparted optimal near infrared (NIR) light-triggered release of doxorubicin (Dox) from conventional sterically stabilized stealth liposomes. The type and amount of PoP affected drug loading, serum stability and drug release induced by NIR light. Cholesterol and PEGylation were required for Dox loading, but slowed light-triggered release. Dox in stealth PoP liposomes had a long circulation half-life in mice of 21.9 h and was stable in storage for months. Following intravenous injection and NIR irradiation, Dox deposition increased ∼7 fold in treated subcutaneous human pancreatic xenografts. Phototreatment induced mild tumor heating and complex tumor hemodynamics. A single chemophototherapy treatment with Dox-loaded stealth PoP liposomes (at 5–7 mg/kg Dox) eradicated tumors while corresponding chemo- or photodynamic therapies were ineffective. A low dose 3 mg/kg Dox phototreatment with stealth PoP liposomes was more effective than a maximum tolerated dose of free (7 mg/kg) or conventional long-circulating liposomal Dox (21 mg/kg). To our knowledge, Dox-loaded stealth PoP liposomes represent the first reported long-circulating nanoparticle capable of light-triggered drug release.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (306 K)Download as PowerPoint slide

Keywords
Liposomes; Chemotherapy; Phototherapy; Doxorubicin; Porphyrin-phospholipid; Chemophototherapy
First Page Preview
Doxorubicin encapsulated in stealth liposomes conferred with light-triggered drug release
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 75, January 2016, Pages 193–202
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering