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Biocatalytic reduction of α-keto amides to (R)-α-hydroxy amides using Candida parapsilosis ATCC 7330

Paper ID Volume ID Publish Year Pages File Format Full-Text
55224 47043 2012 8 PDF Available
Title
Biocatalytic reduction of α-keto amides to (R)-α-hydroxy amides using Candida parapsilosis ATCC 7330
Abstract

Biocatalytic reduction of primary and secondary α-keto amides was accomplished using whole cells of Candida parapsilosis ATCC 7330. The primary (R)-α-hydroxy amides were obtained in good enantiomeric excess (up to 94%) and conversion (88–99%) as compared to the secondary (R)-α-hydroxy amides.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (132 K)Download as PowerPoint slideHighlights► Candida parapsilosis ATCC 7330 catalyzed reduction of both primary and secondary α-keto amides. ► Type of N-substitution (alkyl or aryl) in the secondary α-keto amides significantly affected the bioreduction. ► Primary α-keto amides gave good ee and yield of the corresponding (R)-α-hydroxy amides than secondary α-keto amides.

Keywords
Primary α-keto amides; Secondary α-keto amides; Biocatalytic reduction; (R)-α-hydroxy amides; Candida parapsilosis ATCC 7330
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Biocatalytic reduction of α-keto amides to (R)-α-hydroxy amides using Candida parapsilosis ATCC 7330
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Today - Volume 198, Issue 1, 30 December 2012, Pages 345–352
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us