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Basic chiral ionic liquids: A novel strategy for acid-free organocatalysis

Paper ID Volume ID Publish Year Pages File Format Full-Text
55260 47045 2013 7 PDF Available
Title
Basic chiral ionic liquids: A novel strategy for acid-free organocatalysis
Abstract

We present design, synthesis and application of basic chiral ionic liquids based on commercially available (S)-proline. This new set of chiral ionic liquids was specifically designed to replace trifluoroacetic acid in enamine-based organocatalysis for asymmetric CC bond formation. Based on their permanent charge, these chiral ionic liquids could be applied as organocatalysts in asymmetric aldol reaction of 4-nitrobenzaldehyde and acetone, and good yields and selectivities up to 80%ee could be obtained without additional acid.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (116 K)Download as PowerPoint slideHighlights► Basic chiral ionic liquids. ► Acid-free asymmetric aldol reaction. ► Ionic liquids for organocatalysis.

Keywords
Ionic liquids; Organocatalysis; Chirality; Aldol reaction; Asymmetric synthesis
First Page Preview
Basic chiral ionic liquids: A novel strategy for acid-free organocatalysis
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Today - Volume 200, 1 February 2013, Pages 80–86
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis