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Vancomycin-modified LaB6@SiO2/Fe3O4 composite nanoparticles for near-infrared photothermal ablation of bacteria

Paper ID Volume ID Publish Year Pages File Format Full-Text
553 46 2013 7 PDF Available
Title
Vancomycin-modified LaB6@SiO2/Fe3O4 composite nanoparticles for near-infrared photothermal ablation of bacteria
Abstract

LaB6 nanoparticles possess excellent near-infrared (NIR) photothermal conversion properties. Vancomycin can interact strongly with a broad range of Gram-positive and Gram-negative bacteria. Fe3O4 nanoparticles could be used as the carrier for magnetic separation. In this work, vancomycin and Fe3O4 nanoparticles were successfully bound onto the surface of LaB6 nanoparticles with a silica coating and carboxyl functionalization to fabricate vancomycin-modified LaB6@SiO2/Fe3O4 (Van-LaB6@SiO2/Fe3O4) composite nanoparticles as a novel nanomaterial for the NIR photothermal ablation of bacteria. From the analyses of absorption spectra, transmission electron microscopy images and X-ray diffraction patterns, the formation of Van-LaB6@SiO2/Fe3O4 composite nanoparticles was confirmed. The resulting Van-LaB6@SiO2/Fe3O4 composite nanoparticles possessed nearly superparamagnetic properties, retained the excellent NIR photothermal conversion property of LaB6 nanoparticles and could capture the bacteria Staphylococcus aureus and Escherichia coli efficiently. Owing to these capabilities, they were demonstrated to be quite efficient for the magnetic separation and NIR photothermal ablation of S. aureus and E. coli. Furthermore, the magnetic property made the Van-LaB6@SiO2/Fe3O4 composite nanoparticles useful for the magnetic assembling of bacteria, which could further enhance the photothermal ablation efficiency.

Keywords
LaB6 nanoparticles; Vancomycin; Fe3O4; Near infrared photothermal ablation; Bacteria
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Vancomycin-modified LaB6@SiO2/Fe3O4 composite nanoparticles for near-infrared photothermal ablation of bacteria
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 7, July 2013, Pages 7573–7579
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us