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Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Paper ID Volume ID Publish Year Pages File Format Full-Text
5530 397 2015 18 PDF Available
Title
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Abstract

Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of tissue engineering applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental cell research, cell signaling, drug and gene delivery, and bio-sensing.

Keywords
GelMA; Hydrogel; Gelatin; Tissue engineering; Biomedical; Methacryloyl
First Page Preview
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 73, December 2015, Pages 254–271
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering