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Solvent-free, one-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones using sulfuric acid-modified PEG-6000 as a green recyclable and biodegradable polymeric catalyst

Paper ID Volume ID Publish Year Pages File Format Full-Text
55352 47048 2012 8 PDF Available
Title
Solvent-free, one-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones using sulfuric acid-modified PEG-6000 as a green recyclable and biodegradable polymeric catalyst
Abstract

A green practical method for the efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones using sulfuric acid-modified polyethylene glycol-6000 (PEG-OSO3H) as an eco-friendly polymeric catalyst from the four-component condensation reaction of phthalic anhydride, hydrazinium hydroxide, 1,3-cyclohexanedione or 5,5-dimethyl 1,3-cyclohexanedione (dimedone) and aromatic aldehydes under solvent-free conditions at 80 °C is described. This approach allowed the environmental impact factor (E-factor) to be minimized.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (184 K)Download as PowerPoint slideHighlights► Operational simplicity and high yields of products with minimized environmental impact factor. ► Environmental compatibility and non-toxicity, low cost, and ease of isolation. ► Simplified recovery and reusability of catalyst. ► Application of 2H-indazolo[2,1-b]phthalazine-triones in the synthesis of pharmaceuticals and agrochemicals.

Keywords
Multi-component synthesis; 2H-Indazolo[2,1-b]phthalazine-1,6,11(13H)-trione; Solvent-free; PEG-OSO3H; Catalyst; E-factor
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Solvent-free, one-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones using sulfuric acid-modified PEG-6000 as a green recyclable and biodegradable polymeric catalyst
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Today - Volume 196, Issue 1, 30 November 2012, Pages 148–155
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us