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Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model

Paper ID Volume ID Publish Year Pages File Format Full-Text
5560 400 2015 11 PDF Available
Title
Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model
Abstract

Extensive urethral defects have a serious impact on quality of life, and treatment is challenging. A shortage of material for reconstruction is a key limitation. Improving the properties of biomaterials and making them suitable for urethral reconstruction will be helpful. Previously, we constructed a fusion protein, collagen-binding VEGF (CBD-VEGF), which can bind to collagen scaffold, stimulate cell proliferation, and promote angiogenesis and tissue regeneration. We proposed that CBD-VEGF could improve the performance of collagen in reconstruction of extensive urethral defects. Our results showed that collagen scaffolds modified with CBD-VEGF could promote urethral tissue regeneration and improve the function of the neo-urethra in a beagle extensive urethral defect model. Thus, modifying biomaterials with bioactive factors provides an alternative strategy for the production of suitable biomaterials for urethral reconstruction.

Keywords
Collagen; Vascular endothelial growth factors; Urethral regeneration; Collagen-binding domain
First Page Preview
Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 69, November 2015, Pages 45–55
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering