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Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
5565 400 2015 8 PDF Available
Title
Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging
Abstract

Natural biopolymer based multifunctional nanomaterials are perfect candidates for multimodality imaging and therapeutic applications. Conventional methods of building multimodal imaging probe require either cross-linking manners to increase its in vivo stability or attach a target module to realize targeted imaging. In this study, the intrinsic photoacoustic signals and the native strong chelating properties with metal ions of melanin nanoparticle (MNP), and transferrin receptor 1 (TfR1) targeting ability of apoferritin (APF) was employed to construct an efficient nanoplatform (AMF) without tedious assembling process. Smart APF shell significantly increased metal ions loading (molar ratio of 1:800, APF/Fe3+) and therefore improved magnetic resonance imaging (MRI) sensitivity. Moreover, synergistic use of Fe3+ and APF contributed to high photoacounstic imaging (PAI) sensitivity. AMF showed excellent bio-stability and presented good in vivo multimodality imaging (PET/MRI/PAI) properties (good tumor uptake, high specificity and high tumor contrast) in HT29 tumor because of its targeting property combined with the enhanced permeability and retention (EPR) effect, making it promising in theranostics and translational nanomedicine.

Keywords
Apoferritin; Melanin; PET; MRI; PAI
First Page Preview
Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 69, November 2015, Pages 30–37
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering