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Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer

Paper ID Volume ID Publish Year Pages File Format Full-Text
5656 411 2015 10 PDF Available
Title
Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer
Abstract

Oral chemotherapy is the preferred treatment for colon cancer. However, this strategy faces many challenges, including instability in the gastrointestinal (GI) tract, insufficient bioavailability, low tumor targeting, and severe adverse effects. In this study, we designed a novel redox nanoparticle (RNPO) that is an ideal oral therapeutics for colitis-associated colon cancer treatment. RNPO possesses nitroxide radicals in the core, which act as reactive oxygen species (ROS) scavengers. Orally administered RNPO highly accumulated in colonic mucosa, and specifically internalized in cancer tissues, but less in normal tissues. Despite of long-term oral administration of RNPO, no noticeable toxicities were observed in major organs of mice. Because RNPO effectively scavenged ROS, it significantly suppressed tumor growth after accumulation at tumor sites. Combination of RNPO with the conventional chemotherapy, irinotecan, led to remarkably improved therapeutic efficacy and effectively suppressed its adverse effects on GI tract. Therefore, RNPO is promising oral nanotherapeutics for cancer therapies.

Keywords
Redox nanoparticles; Oral therapeutics; ROS; Drug delivery system; Cancer
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Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 55, July 2015, Pages 54–63
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us