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Mapping the CXCR4 receptor on breast cancer cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
5671 412 2015 8 PDF Available
Title
Mapping the CXCR4 receptor on breast cancer cells
Abstract

The CXCR4 receptor triggers cell migration and, in breast cancer, promotes metastasis. To date, the dynamic assembly of CXCR4 on the cell surface as a mediator of receptor binding is not well characterized. The objective of this work is to quantify the density, spatial organization, and magnitude of binding of the CXCR4 receptor on live metastatic breast cancer (MBC) cells. We measured the Young's modulus, the CXCR4 surface density, and CXCR4 unbinding force on MBC cells by atomic force microscopy. We conclude that the CXCR4 density, spatial organization, and matrix stiffness are paramount to achieve strong binding.

Keywords
Atomic force microscopy (AFM); CXCR4; Breast cancer; Young's modulus; Adhesion; Drug delivery
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Mapping the CXCR4 receptor on breast cancer cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 57, July 2015, Pages 161–168
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us