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A facile synthesis of versatile Cu2−xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
5673 412 2015 10 PDF Available
Title
A facile synthesis of versatile Cu2−xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging
Abstract

A novel type of intelligent nanoprobe by using single component of Cu2−xS for multimodal imaging has been facilely and rapidly synthesized in scale via thermal decomposition followed by biomimetic phospholipid modification, which endows them with uniform and small nanoparticle size (ca.15 nm), well phosphate buffer saline (PBS) dispersity, high stability, and excellent biocompatibility. The as-synthesized Cu2−xS nanoprobes (Cu2−xS NPs) are capable of providing contrast enhancement for T1-weighted magnetic resonance imaging (MRI), as demonstrated by the both in vitro and in vivo imaging investigations for the first time. In addition, due to their strong near infrared (NIR) optical absorption, they can also serve as a candidate contrast agent for enhanced infrared thermal/photoacoustic imaging, to meet the shortfalls of MRI. Hence, complementary and potentially more comprehensive information can be acquired for the early detection and accurate diagnosis of cancer. Furthermore, negligible systematic side effects to the blood and tissue were observed in a relatively long period of 3 months. The distinctive multimodal imaging capability with excellent hemo/histocompatibility of the Cu2−xS NPs could open up a new molecular imaging possibility for detecting and diagnosing cancer or other diseases in the future.

Graphical abstractA novel type of intelligent nanoprobe Cu2−xS for enhanced magnetic resonance (MR)/infrared thermal/photoacoustic multimodal imaging was firstly proposed and facilely synthesized in scale via thermal decomposition followed by biomimetic phospholipid modification to meet the requirements of intravenous injection. The as-synthesized Cu2−xS NPs are capable of providing both in vitro and in vivo significant contrast enhancement for T1-weighted MR/infrared thermal/photoacoustic multimodal imaging, with negligible systematic side effects to the blood and normal tissues, and show great prospects in medical imaging for the early and accurate diagnosis of cancers.Figure optionsDownload full-size imageDownload high-quality image (325 K)Download as PowerPoint slide

Keywords
Cu2−xS nanoprobe; Magnetic resonance imaging; Infrared thermal imaging; Photoacoustic imaging; Contrast agent
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A facile synthesis of versatile Cu2−xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 57, July 2015, Pages 12–21
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us