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In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
568 51 2013 13 PDF Available
Title
In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass ☆
Abstract

In order to enhance the corrosion resistance of the Ca65Mg15Zn20 bulk metallic glass, which has too fast a degradation rate for biomedical applications, we fabricated the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass because of the unique properties of high-entropy alloys. Our results showed that the mechanical properties and corrosion behavior were enhanced. The in vitro tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass could stimulate the proliferation and differentiation of cultured osteoblasts. The in vivo animal tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass did not show any obvious degradation after 4 weeks of implantation, and they can promote osteogenesis and new bone formation after 2 weeks of implantation. The improved mechanical properties and corrosion behavior can be attributed to the different chemical composition as well as the formation of a unique high-entropy atomic structure with a maximum degree of disorder.

Keywords
Ca20Mg20Zn20Sr20Yb20 alloy; High-entropy alloys; Bulk metallic glasses; Biodegradable metals; Bone
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In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 10, November 2013, Pages 8561–8573
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us