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A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape

Paper ID Volume ID Publish Year Pages File Format Full-Text
5707 417 2015 7 PDF Available
Title
A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape
Abstract

An important aspect in the design of nanomaterials for delivery is an understanding of its uptake and ultimate release to the cytosol of target cells. Real-time chemical sensing using a nanoparticle-based platform affords exquisite insight into the trafficking of materials and their cargo into cells. This versatile and tunable technology provides a powerful tool to probe the mechanism of cellular entry and cytosolic delivery of a variety of materials, allowing for a simple and convenient means to screen materials towards efficient delivery of therapeutics such as nucleic acids.

Keywords
Nanoparticle; Endosomal escape; Chemical sensing; Delivery; Nanotechnology
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A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 51, May 2015, Pages 250–256
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us