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Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
5733 423 2015 10 PDF Available
Title
Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging
Abstract

A novel type of self-fluorescent unimolecular micelle nanoparticle (NP) formed by multi-arm star amphiphilic block copolymer, Boltron® H40 (H40, a 4th generation hyperbranched polymer)-biodegradable photo-luminescent polymer (BPLP)-poly(ethylene glycol) (PEG) conjugated with cRGD peptide (i.e., H40-BPLP-PEG-cRGD) was designed, synthesized, and characterized. The hydrophobic BPLP segment was self-fluorescent, thereby making the unimolecular micelle NP self-fluorescent. cRGD peptides, which can effectively target αvβ3 integrin-expressing tumor neovasculature and tumor cells, were selectively conjugated onto the surface of the micelles to offer active tumor-targeting ability. This unique self-fluorescent unimolecular micelle exhibited excellent photostability and low cytotoxicity, making it an attractive bioimaging probe for NP tracking for a variety of microscopy techniques including fluorescent microscopy, confocal laser scanning microscopy (CLSM), and two-photon microscopy. Moreover, this self-fluorescent unimolecular micelle NP also demonstrated excellent stability in aqueous solutions due to its covalent nature, high drug loading level, pH-controlled drug release, and passive and active tumor-targeting abilities, thereby making it a promising nanoplatform for targeted cancer theranostics.

Keywords
Self-fluorescence; Unimolecular micelles; Drug nanocarrier; Drug delivery; Bioimaging probe; Cancer theranostics
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Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 47, April 2015, Pages 41–50
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us