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Photo-induced inhibition of Alzheimer's β-amyloid aggregation in vitro by rose bengal

Paper ID Volume ID Publish Year Pages File Format Full-Text
5788 431 2015 7 PDF Available
Title
Photo-induced inhibition of Alzheimer's β-amyloid aggregation in vitro by rose bengal
Abstract

The abnormal aggregation of β-amyloid (Aβ) peptides in the brain is a major pathological hallmark of Alzheimer's disease (AD). The suppression (or alteration) of Aβ aggregation is considered to be an attractive therapeutic intervention for treating AD. We report on visible light-induced inhibition of Aβ aggregation by xanthene dyes, which are widely used as biomolecule tracers and imaging markers for live cells. Among many xanthene dyes, rose bengal (RB) under green LED illumination exhibited a much stronger inhibition effect upon photo-excitation on Aβ aggregation than RB under dark conditions. We found that RB possesses high binding affinity to Aβ; it exhibits a remarkable red shift and a strong enhancement of fluorescence emission in the presence of Aβ. Photo-excited RB interfered with an early step in the pathway of Aβ self-assembly and suppressed the conformational transition of Aβ monomers into β-sheet-rich structures. Photo-excited RB is not only effective in the inhibition of Aβ aggregation, but also in the reduction of Aβ-induced cytotoxicity.

Keywords
Peptide self-assembly; Beta-amyloid; Photosensitizers; Inhibitors; Rose bengal
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Photo-induced inhibition of Alzheimer's β-amyloid aggregation in vitro by rose bengal
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 38, January 2015, Pages 43–49
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us