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Enhanced dual contrast agent, Co2+-doped NaYF4:Yb3+,Tm3+ nanorods, for near infrared-to-near infrared upconversion luminescence and magnetic resonance imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
5814 437 2014 10 PDF Available
Title
Enhanced dual contrast agent, Co2+-doped NaYF4:Yb3+,Tm3+ nanorods, for near infrared-to-near infrared upconversion luminescence and magnetic resonance imaging
Abstract

Dual-modality imaging with magnetic resonance (MR) and upconversion luminescence (UCL) is a promising technique for molecular imaging in biomedical research. Multifunctional lanthanide-based nanoparticles have been widely investigated as agents for contrast enhanced MR and fluorescence imaging. However, the use of rare earth fluoride nanoparticles for dual-modality imaging of T2-weighted MR and UCL is rarely reported. We find that NaYF4:Yb3+,Tm3+,Co2+ (MUC) nanorods can be applied as a high-performance dual contrast agent for both T2-weighted MR and UCL dual-modality imaging. After modification with 6-O-carboxymethyl chitosan (OCC), MUC nanorods can be endocytosed by cells without showing signs of cytotoxicity. High-quality UCL images of living cells incubated with MUC-OCC nanorods were acquired on a near-infrared (NIR) confocal microscopy under the excitation at 980 nm. Moreover, MUC-OCC nanorods display high transverse (r2) relaxivities in vitro. The application of low-dose MUC-OCC nanorods for NIR-to-NIR UCL and MR dual-modality in vivo imaging was also carried out successfully. In addition, the toxicity of MUC-OCC nanorods was evaluated by MTT assay, serological tests and histological analysis of visceral organs.

Keywords
Upconversion luminescence; Nanorod; Magnetic resonance imaging; Multi-modality imaging; Rare earth nanomaterials; Lanthanide nanoparticle
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Enhanced dual contrast agent, Co2+-doped NaYF4:Yb3+,Tm3+ nanorods, for near infrared-to-near infrared upconversion luminescence and magnetic resonance imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 35, Issue 33, November 2014, Pages 9167–9176
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us