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Bio-orthogonal and combinatorial approaches for the design of binding growth factors

Paper ID Volume ID Publish Year Pages File Format Full-Text
5964 452 2013 10 PDF Available
Title
Bio-orthogonal and combinatorial approaches for the design of binding growth factors
Abstract

Merrifield chemistry enables the convenient synthesis of oligonucleotides and peptides, while recombinant DNA technology has facilitated protein engineering. Recently, protein engineering has been extended into bio-orthogonal protein engineering by the development of specific chemical or enzymatic modification technologies. The combinatorial approach of molecular evolutionary engineering (or in vitro selection) has also provided a new design tool for functional peptides. These methodologies have enabled the development of various new proteinaceous materials for biological and medical applications. Here, we will discuss recent progress in the molecular design of proteins with respect to the preparation of binding growth factors, which are of increasing importance in the biomaterials field.

Keywords
Growth factor; Bio-orthogonal chemistry; Combinatorial chemistry; Molecular evolutionary engineering; Protein engineering
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Bio-orthogonal and combinatorial approaches for the design of binding growth factors
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 31, October 2013, Pages 7565–7574
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us