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Indocyanine green loaded SPIO nanoparticles with phospholipid-PEG coating for dual-modal imaging and photothermal therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
5978 452 2013 9 PDF Available
Title
Indocyanine green loaded SPIO nanoparticles with phospholipid-PEG coating for dual-modal imaging and photothermal therapy
Abstract

A biodegradable nanotheranostic agent has been successfully constructed for fluorescence/magnetic resonance dual-modal imaging guided photothermal therapy by loading indocyanine green (ICG) molecules into 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)] (DSPE-PEG) coated superparamagnetic iron oxide (SPIO) nanoparticles (NPs). It was proved that the obtained SPIO@DSPE-PEG/ICG NPs with an average diameter around 27.4 nm could serve as an efficient probe to simultaneously enhance fluorescence imaging and magnetic resonance imaging greatly in vivo. After tail vein injection, the SPIO@DSPE-PEG/ICG NPs were found selectively accumulate at the tumor site. Encapsulation of ICG into the lipid coating of SPIO NPs results in higher photostability than free ICG due to the protection from degradation. SPIO@DSPE-PEG/ICG NPs exhibited significant photothermal cytotoxicity. Cancer cells could be killed in vitro and tumors could be ablated in vivo efficiently through photothermal effects of SPIO@DSPE-PEG/ICG NPs under laser irradiation. In summary, SPIO@DSPE-PEG/ICG NPs integrate multiple capabilities for effective tumor imaging and therapy. This is very helpful for accurately interpreting the obtained images, identifying the size and location of the tumor, as well as guiding and monitoring the photothermal therapy through a single agent.

Keywords
Indocyanine green; SPIO nanoparticles; MRI; Fluorescence imaging; Photothermal therapy
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Indocyanine green loaded SPIO nanoparticles with phospholipid-PEG coating for dual-modal imaging and photothermal therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 31, October 2013, Pages 7706–7714
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us