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Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
5979 452 2013 10 PDF Available
Title
Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy
Abstract

Theranostics, the integration of diagnostics and therapies, has become a new concept in the battles with various major diseases such as cancer. Here, we report a multifunctional nanoplatform, which is developed by covalently grafting core–shell structured upconversion nanoparticles (UCNPs) with nanographene oxide (NGO) via bifunctional polyethylene glycol (PEG), and then loading phthalocyanine (ZnPc) on the surface of NGO. The obtained UCNPs-NGO/ZnPc nanocomposites are not only be used as upconversion luminescence (UCL) imaging probes of cells and whole-body animals with high contrast for diagnosis, but also can generate cytotoxic singlet oxygen under light excitation for photodynamic therapy (PDT), as well as rapidly and efficiently convert the 808 nm laser energy into thermal energy for photothermal therapy (PTT). A remarkably improved and synergistic therapeutic effect compared to PTT or PDT alone is obtained, providing high therapeutic efficiency for cancer treatment. Therefore, benefiting from the unique multifunctional hybrid nanostructure, UCNPs-NGO/ZnPc nanocomposites developed herein are promising as an integrated theranostic probe for potential UCL image-guided combinatorial PDT/PTT of cancer.

Keywords
Multifuntional nanoplatform; Upconversion luminescence imaging; Photothermal therapy; Photodynamic therapy; Synergistic effect
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Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 31, October 2013, Pages 7715–7724
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us