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Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential

Paper ID Volume ID Publish Year Pages File Format Full-Text
600 52 2012 13 PDF Available
Title
Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential
Abstract

The design of antimicrobial polymers to address healthcare issues and minimize environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol–gel chemical route; these compounds possess flexible Si–O–Si bonds. In present work, a partially hydrolyzed QAMS co-polymerized with 2,2-[4(2-hydroxy 3-methacryloxypropoxy)-phenyl]propane is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. The kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC 12104) and Candida albicans (ATCC 90028). Improved mechanical properties after hydration provided the proof-of-concept that QAMS-incorporated resin exhibits self-repair potential via water-induced condensation of organic modified silicate (ormosil) phases within the polymerized resin matrix.

Keywords
Quaternary ammonium; Organic modified silicate; Antimicrobial; Sol–gel technique; Self-repair
First Page Preview
Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 9, September 2012, Pages 3270–3282
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering