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Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
6076 457 2014 11 PDF Available
Title
Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery
Abstract

To create advanced functional nanocarriers for achieving excellent gene delivery performance, fluorescence label-free hybridized dendrimer-like silica nanocarriers (HPSNs-AC-PEI) were developed by using the endosomal pH and cytoplasmic glutathione (GSH) responsive autofluorescent acetaldehyde-modified-cystine (AC) to link non-toxic low molecular weight branched polyethyleneimine (PEI) onto amino-functionalized dendrimer-like silica nanoparticles with hierarchical pores (HPSNs-NH2). The specific microstructure of this hybridized nanocarrier makes it not only show low cytotoxicity and high gene loading capability, but also display high gene transfection efficiency. The cleavage of disulfide bonds caused by GSH facilitates plasmid DNA (pDNA) release. Moreover, the pH and GSH controlled gene delivery profile can be real–time tracked using the autofluorescence of HPSNs-AC-PEI.

Keywords
Mesoporous silica; Dendrimer-like; Fluorescence; GSH; Responsive; Gene delivery
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Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 35, Issue 21, July 2014, Pages 5580–5590
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us