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Genipin-cross-linked fucose–chitosan/heparin nanoparticles for the eradication of Helicobacter pylori

Paper ID Volume ID Publish Year Pages File Format Full-Text
6123 463 2013 14 PDF Available
Title
Genipin-cross-linked fucose–chitosan/heparin nanoparticles for the eradication of Helicobacter pylori
Abstract

Helicobacter pylori is a significant human pathogen that recognizes specific carbohydrate receptors, such as the fucose receptor, and produces the vacuolating cytotoxin, which induces inflammatory responses and modulates the cell–cell junction integrity of the gastric epithelium. The clinical applicability of topical antimicrobial agents was needed to complete the eradication of H. pylori in the infected fundal area. In the present study, we combined fucose-conjugated chitosan and genipin-cross-linking technologies in preparing multifunctional genipin-cross-linked fucose–chitosan/heparin nanoparticles to encapsulate amoxicillin of targeting and directly make contact with the region of microorganism on the gastric epithelium. The results show that the nanoparticles effectively reduced drug release at gastric acids and then released amoxicillin in an H. pylori survival situation to inhibit H. pylori growth and reduce disruption of the cell–cell junction protein in areas of H. pylori infection. Furthermore, with amoxicillin-loaded nanoparticles, a more complete H. pylori clearance effect was observed, and H. pylori–associated gastric inflammation in an infected animal model was effectively reduced.

Keywords
Fucose-conjugated chitosan; Genipin-cross-linked nanoparticles; Helicobacter pylori; Gastric inflammation; Infected animal model
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Genipin-cross-linked fucose–chitosan/heparin nanoparticles for the eradication of Helicobacter pylori
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 18, June 2013, Pages 4466–4479
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us