fulltext.study @t Gmail

An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
6125 463 2013 8 PDF Available
Title
An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery
Abstract

An approach for application of cell penetration to selective small interference RNA (siRNA) localized delivery system, cell penetrable nano-polyplex assembled hydrogel system, is presented. The cell penetrable nano-polyplex assembled hydrogelisprepared by protamine conjugation to poly(organophos-phazene) and inducement of nano-polyplexes with siRNAs. After an injection of cell penetrable nano-polyplex solution into the body, it turns into a gel due to thermosensitivity of poly(organo- phosphazene). The gel maintains up to 4 weeks and the released 30 nm-sized nano-polyplexes from the gel induces highly effective siRNA delivery due to cell penetration. Accordingly, the new system shows a high gene silencing efficiency on only the target site in long-term with a single injection.

Keywords
Cell penetration; Gene delivery; Nano-polyplex; Polyplex hydrogel; Small interference RNA (siRNA)
First Page Preview
An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 18, June 2013, Pages 4493–4500
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering