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The effect of gamma keratose on cell viability in vitro after thermal stress and the regulation of cell death pathway-specific gene expression

Paper ID Volume ID Publish Year Pages File Format Full-Text
6136 464 2014 10 PDF Available
Title
The effect of gamma keratose on cell viability in vitro after thermal stress and the regulation of cell death pathway-specific gene expression
Abstract

When skin is thermally burned, transfer of heat energy into the skin results in the destruction of cells. Some of these cells are damaged but may be capable of self-repair and survival, thereby contributing to spontaneous healing of the wound. Keratin protein-based biomaterials have been suggested as potential treatments for burn injury. Isolation of cortical proteins from hair fibers results in an acid soluble fraction of keratin proteins referred to as “gamma” keratose. In the present study, treatment with this fraction dissolved in media was able to maintain cell viability after thermal stress in an in vitro model using primary mouse dermal fibroblasts. PCR array analysis demonstrated that gamma keratose treatment may assist in the survival and salvage of thermally stressed cells by maintaining their viability through regulation of cell death pathway-related genes. Gamma keratose may be a promising biomaterial for burn treatment that aids in spontaneous wound healing from viable tissue surrounding the burn.

Keywords
Keratin; Thermal; Apoptosis; Autophagy; Burn; Skin
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The effect of gamma keratose on cell viability in vitro after thermal stress and the regulation of cell death pathway-specific gene expression
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 35, Issue 16, May 2014, Pages 4646–4655
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
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