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Treatment of diabetes mellitus with microencapsulated fetal human liver (FH-B-TPN) engineered cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
6152 466 2013 11 PDF Available
Title
Treatment of diabetes mellitus with microencapsulated fetal human liver (FH-B-TPN) engineered cells
Abstract

Transplantation of whole human pancreases or isolated islets into patients with type 1 diabetes mellitus has been severely hampered by the scarcity of cadaveric human donor organs, which mandates search for insulin producing cells/tissue source alternatives. Recent progress in stem cell biology has started looking into functionally competent, insulin-secreting progenitor cells. It had been previously observed that induced expression of the β-cell transcriptional factor of the pancreatic and duodenal homeobox gene1 (PDX1), in human hepatocytes, may activate multiple features of the β-cell phenotype. These “FH-B-TPN” cells were shown to release insulin in response to physiological glucose stimulation both, in vitro and in vivo. However, because FH-B-TPNs lack the expression of a number of β-cell or non β-cell genes, and are associated with low insulin content, we aimed to determine whether these cells, upon physical manipulation and envelopment within “clinical grade” alginate-based microcapsules, would reverse hyperglycemia after graft into diabetic animal models.

Keywords
Fetal liver; Cell therapy; Alginate; Microencapsulation; Diabetes; Transplantation
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Treatment of diabetes mellitus with microencapsulated fetal human liver (FH-B-TPN) engineered cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 16, May 2013, Pages 4002–4012
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us