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Polymer-coated mesoporous silica nanoparticles for the controlled release of macromolecules

Paper ID Volume ID Publish Year Pages File Format Full-Text
616 52 2012 7 PDF Available
Title
Polymer-coated mesoporous silica nanoparticles for the controlled release of macromolecules
Abstract

With the goal of achieving constant release of large biological molecules over an extended period of time we focused on hybrid inorganic/organic nanoparticles. We synthesized poly(ethylene glycol) (PEG)-coated mesoporous silica nanoparticles (MSNs) with incorporated trypsin inhibitor (TI), a model protein molecule for growth factors. Due to the goal of incorporating large protein molecules the pore size of the as-synthesized MSNs was expanded by a hydrothermal treatment prior to TI incorporation. In vitro release from the MSNs without the thin polymer film shows an initial burst followed by continuous release. In the case of polymer-coated MSNs the initial burst release was completely suppressed and approximate zero order release was achieved for 4 weeks.

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Keywords
Controlled release; Mesoporous; Silica; Trypsin inhibitor; Poly(ethylene glycol)
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Polymer-coated mesoporous silica nanoparticles for the controlled release of macromolecules
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 9, September 2012, Pages 3429–3435
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us