fulltext.study @t Gmail

Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking

Paper ID Volume ID Publish Year Pages File Format Full-Text
6191 468 2014 12 PDF Available
Title
Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking
Abstract

In the present study, four phosphorescent iridium(III) complexes [Ir(C–N)2(PhenSe)]+ (Ir1–Ir4, in which C–N = 2-(2,4-difluorophenyl)pyridine (dfppy), dibenzo[f,h]quinoxaline (dbq), 2-phenylquinoline (2-pq) and 2-phenylpyridine (ppy), PhenSe = 1,10-phenanthrolineselenazole) with tunable emission colors were developed to image mitochondria and track the dynamics of the mitochondrial morphology. In comparison with commercially available mitochondrial trackers, Ir1–Ir4 possess high specificity to mitochondria in live and fixed cells without requiring prior membrane permeabilization or the replacement of the culture medium. Due to the high resistance of Ir1–Ir4 to the loss of mitochondrial membrane potential as well as the appreciable tolerance to environmental changes, these complexes are applicable for the imaging and tracking of the mitochondrial morphological changes over long periods of time. In addition, Ir2–Ir4 exhibited superior photostability compared to the commercially available mitochondrial trackers. These colorful iridium(III) complexes may contribute to the future development of staining agents for organelle-selective imaging in living cells.

Keywords
Iridium(III) complex; Phosphorescence; Probe; Mitochondria; Imaging; Tracking
First Page Preview
Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 35, Issue 1, January 2014, Pages 2–13
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us