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A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle

Paper ID Volume ID Publish Year Pages File Format Full-Text
6223 468 2014 7 PDF Available
Title
A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle
Abstract

A cancer-recognizable MRI contrast agents (CR-CAs) has been developed using pH-responsive polymeric micelles. The CR-CAs with pH sensitivity were self-assembled based on well-defined amphiphilic block copolymers, consisting of methoxy poly(ethylene glycol)-b-poly(l-histidine) (PEG-p(l-His)) and methoxy poly(ethylene glycol)-b-poly(l-lactic acid)-diethylenetriaminopentaacetic acid dianhydride-gadolinium chelate (PEG-p(l-LA)-DTPA-Gd). The CR-CAs have a spherical shape with a uniform size of ∼40 nm at physiological pH (pH 7.4). However, in acidic tumoral environment (pH 6.5), the CR-CAs were destabilized due to the protonation of the imidazole groups of p(l-His) blocks, causing them to break apart into positively charged water-soluble polymers. As a result, the CR-CAs exhibit highly effective T1 MR contrast enhancement in the tumor region, which enabled the detection of small tumors of ∼3 mm3in vivo at 1.5 T within a few minutes.

Keywords
Cancer diagnosis; Magnetic resonance imaging; Micelles; Imaging agents; pH-responsive materials
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A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 35, Issue 1, January 2014, Pages 337–343
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
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