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Specific lipase-responsive polymer-coated gadolinium nanoparticles for MR imaging of early acute pancreatitis

Paper ID Volume ID Publish Year Pages File Format Full-Text
6225 468 2014 12 PDF Available
Title
Specific lipase-responsive polymer-coated gadolinium nanoparticles for MR imaging of early acute pancreatitis
Abstract

Currently, available methods for diagnosis of acute pancreatitis (AP) are mainly dependent on serum enzyme analysis and imaging techniques that are too low in sensitivity and specificity to accurately and promptly diagnose AP. The lack of early diagnostic tools highlights the need to search for a highly effective and specific diagnostic method. In this study, we synthesized a conditionally activated, gadolinium-containing, nanoparticle-based MRI nanoprobe as a diagnostic tool for the early identification of AP. Gadolinium diethylenetriaminepentaacetic fatty acid (Gd-DTPA-FA) nanoparticles were synthesized by conjugation of DTPA-FA ligand and gadolinium acetate. Gd-DTPA-FA exhibited low cytotoxicity and excellent biocompatibility when characterized in vitro and in vivo studies. L-arginine induced a gradual increase in the intensity of the T1-weighted MRI signal from 1 h to 36 h in AP rat models. The increase in signal intensity was most significant at 1 h, 6 h and 12 h. These results suggest that the Gd-DTPA-FA as an MRI contrast agent is highly efficient and specific to detect early AP.

Keywords
Gadolinium; Magnetic resonance imaging; Nanoparticle; Diagnosis; Acute pancreatitis; Conditional activation
First Page Preview
Specific lipase-responsive polymer-coated gadolinium nanoparticles for MR imaging of early acute pancreatitis
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 35, Issue 1, January 2014, Pages 356–367
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering