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Cysteine modified rare-earth up-converting nanoparticles for in vitro and in vivo bioimaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
6228 468 2014 6 PDF Available
Title
Cysteine modified rare-earth up-converting nanoparticles for in vitro and in vivo bioimaging
Abstract

Cysteine, as a small organic molecule and amino acid, is a basic building block for proteins and has special physiological functions in vivo. Cysteine has strong affinity for cells, which can be taken advantage for various applications. A new and facile surface modification method has been developed for rare-earth doped upconversion nanoparticles (UCNs) using cysteine. Compared with unmodified samples, the water-solubility and biocompatibility of the cysteine modified NaYF4:Yb,Er and NaYF4:Yb,Tm UCNs (termed as UCN-Er-Cys and UCN-Tm-Cys, respectively) have been significantly improved, while their particle size and emission properties did not change substantially. Due to the low cytotoxicity as revealed by methyl thiazolyl tetrazolium assay, the cysteine modified UCNs were successfully applied to imaging of Hela cells in vitro and nude mouse in vivo. Most significant is that the method offers the advantages of ease of synthesis and handling as well as potentially low cost for biomedical emerging applications.

Keywords
Cysteine; Modification; Upconversion nanoparticles; Biocompatibility; Bioimaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 35, Issue 1, January 2014, Pages 387–392
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us