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Cyclodextrins in non-viral gene delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
6230 468 2014 11 PDF Available
Title
Cyclodextrins in non-viral gene delivery
Abstract

Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. They consist of (α-1,4)-linked glucose units, and possess a basket-shaped topology with an “inner–outer” amphiphilic character. Over the years, substantial efforts have been undertaken to investigate the possible use of CDs in drug delivery and controlled drug release, yet the potential of CDs in gene delivery has received comparatively less discussion in the literature. In this article, we will first discuss the properties of CDs for gene delivery, followed by a synopsis of the use of CDs in development and modification of non-viral gene carriers. Finally, areas that are noteworthy in CD-based gene delivery will be highlighted for future research. Due to the application prospects of CDs, it is anticipated that CDs will continue to emerge as an important tool for vector development, and will play significant roles in facilitating non-viral gene delivery in the forthcoming decades.

Keywords
Cyclodextrin; Gene delivery; Non-viral vector; Polymer; Transfection
First Page Preview
Cyclodextrins in non-viral gene delivery
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 35, Issue 1, January 2014, Pages 401–411
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering