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Controlled release from a mechanically-stimulated thermosensitive self-heating composite hydrogel

Paper ID Volume ID Publish Year Pages File Format Full-Text
6235 468 2014 6 PDF Available
Title
Controlled release from a mechanically-stimulated thermosensitive self-heating composite hydrogel
Abstract

Temperature has been extensively explored as a trigger to control the delivery of a payload from environment-sensitive polymers. The need for an external heat source only allows limited spatiotemporal control over the delivery process. We propose a new approach by using the dissipative properties of a hydrogel matrix as an internal heat source when the material is mechanically loaded. The system is comprised of a highly dissipative hydrogel matrix and thermo-sensitive nanoparticles that shrink upon an increase in temperature. Exposing the hydrogel to a cyclic mechanical loading for a period of 5 min leads to an increase of temperature of the nanoparticles. The concomitant decrease in the volume of the nanoparticles increases the permeability of the hydrogel network facilitating the release of its payload. As a proof-of-concept, we showed that the payload of the hydrogel is released after 5–8 min following the initiation of the mechanical loading. This delivery method would be particularly suited for the release of growth factor as it has been shown that cell receptor to growth factor is activated 5–20 min following a mechanical loading.

Keywords
Hydrogel; Controlled release; Mechanical loading; Viscous dissipation; Thermosensitive nanoparticles
First Page Preview
Controlled release from a mechanically-stimulated thermosensitive self-heating composite hydrogel
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 35, Issue 1, January 2014, Pages 450–455
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering